kidney diaease
he Genetic Background of PKD
Autosomal dominant polycystic kidney disease mainly has two genes, which are named respectively as PKD1 and pkd2.
PKD1 gene is located on the short arm of chromosome sixteenth (16p13.3), which encodes a protein called polycystic protein 1 (polycystin-1), PKD1 gene mutation caused by ADPKD accounted for 85%~90%; PKD2 located on the long arm of chromosome fourth (4q22), encoding a protein called polycystic protein 2 (polycysti-2), PKD2 gene mutation accounted for 5%~15%.
The age of clinical manifestations and renal failure of polycystic kidney disease caused by PKD1 gene mutation is than the PKD caused by PKD2 gene mutation for early ten years.
The diabetic kidney disease is a most common complication. Once diagnosed with it, the metabolism will be disorder. For the diabetic kidney disease, it is difficult to treat than other kidney diseases if develop into end stage. Therefore, we should notice the followings so as to prevent timely.
1、Do a 24h urine micro protein examination in a standard hospital timely.
2、Measure blood pressure regularly, it is better to measure it every week. At the same time, control the blood pressure and blood sugar well.
3、Follow doctor’s advice, chose proper hypotensor and take it regularly.
Pay attention to your daily life and keep good habit of observing your physical condition, for example, observe your urine.
Autosomal dominant polycystic kidney disease mainly has two genes, which are named respectively as PKD1 and pkd2.
PKD1 gene is located on the short arm of chromosome sixteenth (16p13.3), which encodes a protein called polycystic protein 1 (polycystin-1), PKD1 gene mutation caused by ADPKD accounted for 85%~90%; PKD2 located on the long arm of chromosome fourth (4q22), encoding a protein called polycystic protein 2 (polycysti-2), PKD2 gene mutation accounted for 5%~15%.
The age of clinical manifestations and renal failure of polycystic kidney disease caused by PKD1 gene mutation is than the PKD caused by PKD2 gene mutation for early ten years.
The diabetic kidney disease is a most common complication. Once diagnosed with it, the metabolism will be disorder. For the diabetic kidney disease, it is difficult to treat than other kidney diseases if develop into end stage. Therefore, we should notice the followings so as to prevent timely.
1、Do a 24h urine micro protein examination in a standard hospital timely.
2、Measure blood pressure regularly, it is better to measure it every week. At the same time, control the blood pressure and blood sugar well.
3、Follow doctor’s advice, chose proper hypotensor and take it regularly.
Pay attention to your daily life and keep good habit of observing your physical condition, for example, observe your urine.
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