what is FSGS ?

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what is FSGS ?

Focal Segmental Sclerosis Glomerulonephritis，which is a traditional saying，we get the diagnosis according to traditional diagnostic method。The traditional diagnostic method is to observe nephritic structure histologically and then get the result. But for advanced medical diagnosis at present, we can call this disease Epithelial Cells of the Glomerulus from a cellular perspective. For now, our hospital analyzes kidney disease based on analyzing kidney diagnosis from a cellular perspective.

Causes of FSGS

The main cause of disease can be divided into two groups, intrarenal reason like people with low immunity oneself and extrarenal reason like infection, having a cold and so on, when antigens invade the human body.
●The main reason why you get the disease is your own immunity decrease, this can cause inflammatory cells to invade the kidney, resulting immune complexes deposits in the body. These immune complexes deposit in the glomerular capillary loops, and those immune complexes that deposit in the epithelial cells are caused by infection of inflammatory cells. In the modern cytology, some of the glomerular are not all sclerosis, but we can see the hyaline change in the sclerosis, so it is called focal diseases, and we call it Focal Segmental Sclerosis Glomerulonephritis, also focal glomerulus epithelial cell disease.

●They will react with the antibodies then forming antigen antibody immune complex(mainly based on nonspecific IGM and C3 sedimentation),as blood circulation deposit in glomerular capillary, the segment hyaline of epithelial cells of glomerulus degenerate, the epithelial cells surface of glomerulus strip, foot processes fuse extensively, focal basement membrane atrophy, inflammatory mediator infiltrate further, thus leading to the original synthesis with negatively charged barrier function of epithelial cell will be damaged. After this function being damaged, the protein with negative charge in the blood can be damaged because of the epithelial cells barrier function, then getting into the urine without any obstacles and excrete with the urine. In the meantime, after being damaged, epithelial cells transform into myofibroblast, causing glomerular sclerosis, starting renal fibrosis process.http://www.my-kidney.org/kidney-treatment-cost.html